Ivermectin is a broad-spectrum antiparasitic agent from the avermectin family, originally derived from Streptomyces avermitilis. It works by binding to glutamate-gated chloride channels in invertebrate nerve and muscle cells, increasing membrane permeability and causing paralysis and death of the parasite. Ivermectin is widely used to treat onchocerciasis (river blindness), lymphatic filariasis, strongyloidiasis, scabies, and other helminthic and ectoparasitic infections. Its proven efficacy and safety have made it integral to mass drug administration efforts in endemic regions.
Applications: Primarily used in research for parasitic diseases, including river blindness and lymphatic filariasis.
